Deactivation of macrophages by transforming growth factor-β

摘要: Macrophage activation—enhanced capacity to kill, in a cell that otherwise mostly scavenges—is essential for host survival from infection and contributes containment of tumours. Both microbes tumour cells, therefore, may be under pressure inhibit or reverse the activation macrophages. This reasoning led demonstration macrophage deactivating factors both microbes1,2 cells3–5. In some circumstances itself probably requires ability deactivate Macrophages are healing wounds repair tissues damaged by inflammation. Yet cytotoxic products activated macrophages can damage endothelium, fibroblasts, smooth muscle parenchymal cells (reviewed ref. 6). Thus, after an inflammatory site has been sterilized, impact on might shift benefit detriment. These concepts us search effects among polypeptide growth regulate angiogenesis, fibrogenesis other aspects tissue repair. Among 11 such factors, two proteins 71% similar proved potent deactivators: these transforming factor-β1 (TGF- β1) TGF- β2.