Immunopathology of experimental cutaneous leishmaniasis.

摘要: Relatively susceptible BALB/c and relatively resistant A/J mice were infected subcutaneously in the right hind footpad with promastigotes of Leishmania mexicana amazonensis. A large localized lesion developed within 2 months after infection mice, while exhibited a small discrete fibrotic nodule. Sequential immunologic histologic examination demonstrated that nodular foam-cell type progressive depression delayed-type hypersensitivity (DTH) response to leishmania antigen, had mixed cellular fibrosing encapsulating reaction maintained positive DTH responses antigen. Anti-leishmania antibody at similar levels both strains. The lesions found bone marrow, tendon, skin appendages, regional lymph nodes, tendency toward cutaneous metastases. Lesions remained localized. Fibrosis, focal fibrinoid necrosis, lymphocytic macrophagic infiltration outstanding features. Light transmission electron microscopic studies indicated no destruction leishmanias seemed occur macrophages either mouse strain. In more however, parasitized frequently necrotic, degenerating often seen free interstitial tissue. These observations help interpretation features, as well pathogenesis, mucocutaneous leishmaniasis man.