Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes.

摘要: Meiotic checkpoints are manifested through protein complexes capable of detecting an abnormality in chromosome metabolism and signaling it to effector molecules that subsequently delay or arrest the progression meiosis. Some act during first meiotic prophase monitor repair chromosomal DSBs, predominantly by recombination, ensure correct establishment synapsis its well-timed dissolution. In mammals, a number checkpoint proteins localize cores, sometimes context synaptonemal complex (SC).1 Here we discuss possible functions these accomplishment recombination normal pathway. Also, present arguments for structural role cores SCs assembly on chromosomes.