The protective effects of berry-derived anthocyanins against visible light-induced damage in human retinal pigment epithelial cells
作者： Yong Wang , Di Zhang , YiXiang Liu , Dan Wang , Jia Liu
DOI: 10.1002/JSFA.6765
关键词:
摘要: BACKGROUND Studies have shown that anthocyanins (ACNs) in berries contribute to eye health. However, information on the relationship between chemical structures and visual functions of ACNs is scarce. This study investigated protection effects with different against visible light-induced damage human retinal pigment epithelial (RPE) cells. RESULTS Four aglycones, namely, pelargonidin-3-glucoside (Pg-3-glu), cyanidin-3-glucoside (Cy-3-glu), delphinidin-3-glucoside, malvidin-3-glucoside (Mv-3-glu), were isolated from three (blueberry, blackberry strawberry). Of these ACNs, Cy-3-glu exhibited highest reactive oxygen species inhibitory capacity RPE cells, 40 µg mL−1 showing a ROS clearance 57.5% ± 4.2%. The expression vascular endothelial growth factor levels significantly (P < 0.05) down-regulated by Mv-3-glu cell model. Pg-3-glu treatments inhibited increase β-galactosidase during ageing caused light exposure. CONCLUSION Our findings suggest biological properties vary. Cy-3-glu, which contains an ortho hydroxyl group its B ring, possibly exerts multiple protective (antioxidant, anti-angiogenic anti-ageing) cells. Therefore, may prove useful as prophylactic health food for prevention diseases. © 2014 Society Chemical Industry
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