Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa.

摘要: Abstract Previous studies of the Hpa I cleavage site-sickle cell hemoglobin gene linkage in various African populations suggested that sickle arose independently more than once. In present study we have performed restriction endonuclease haplotype analysis for beta-globin-like cluster from four separate geographic areas Africa, all which possess gene. Benin (Central West Africa) and Algeria (Arab North chromosomes carrying an identical as defined by 11 different polymorphic sites within 60-kilobase region cluster. Central Republic (Bantu-speaking Senegal (Atlantic a very large proportion were associated with specific each country. Thus, three haplotypes are shown to be is at high frequency geographically regions. Since differ other least residing both 5' 3' putative hot spot recombination, it most likely times on preexisting chromosomal haplotypes. This may implications better understanding variable nature expression anemia, because clinically relevant sequences (for example, gamma-globin regulatory responsive anemia) might linked polymorphically these