Chapter 13. Antiviral Agents

摘要: Publisher Summary This chapter discusses studies on antiviral agents with an emphasis interferon. The role played by interferon in the course of natural varicella infection was studied human patients and without impairment host–defense mechanisms. With normal defense mechanisms, titres present cutaneous vesicles were initially high appeared to prevent virus dissemination allow rapid recovery. On other hand, Hodgkins disease, lymphomas, leukemias, where there is low present, viral some cases led death. In those cases, which resolved favorably, remission followed late appearance titres. animal experiments, it found that macrophages stimulated produce a nonreplicating could be transferred mice already infected encephalomyocarditis (EMC) or Semliki Forest (SFV) exhibiting clinical symptoms. Some early poly IC man have shown titre (1:16) achieved after intravenous administration. No effect prolongation life alleviation disease conditions seen terminal cancer administration IC, but only side noted mild fever.