The Murine Antibody Response to Phosphocholine

摘要: Idiotypic determinants on immunoglobulin molecules serve two very useful purposes—one to the scientist who studies them, other animal that expresses them. For researcher they provide an invaluable probe for of antibody variability, mapping V H and L genes, examining evolution genes. In as targets through which idiotypically specific, regulatory cells or modulate immune responses in a highly selected manner. The work our laboratory has used idiotypy former sense, is, tool investigate diversity response and, because this particular is preserved mice, study chapter we will briefly review events led dissection phosphocholine (PC), process idiotypes play crucial role. We not attempt literature field since PC system attracted many talented investigators. Detailed descriptions much can be found chapters volume reviews.(1–3)