Dynamic Micro-Magnetic Resonance Imaging of Liver Micrometastasis in Mice with a Novel Liver Macromolecular Magnetic Resonance Contrast Agent DAB-Am64-(1B4M-Gd)64
作者： Akira Hiraga , Takayoshi Ishimori , Tsuneo Saga , Kaori Togashi , Satomi Kawamoto
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摘要: DAB-Am64-(1B4M-Gd) 64 is a newly synthesized macromolecular liver magnetic resonance imaging (MRI) contrast agent with polypropylenimine diaminobutane (DAB) dendrimer conjugated bifunctional diethylenetriaminepentaacetic acid (DTPA) derivative for complexing Gd(III) atoms. The characteristics of , which quickly accumulated in the liver, have been reported recently. In present study, dynamic micro-MRI was obtained mouse metastasis model using colon carcinoma cells to evaluate ability visualize micrometastatic tumors compared that Gd-DTPA. able homogeneously enhance normal parenchyma and 0.3-mm diameter mice better than conclusion, new MRI potentially useful diagnosis micrometastasis liver.
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