The Chronic Kidney Disease - Colonic Axis.

摘要: Chronic kidney disease (CKD) has long been known to cause significant gastrointestinal and colonic pathology. Recent advances in understanding of the role bacterial microbiome its function composition health have revealed previously unappreciated effects CKD-associated pathology on development uremic complications. CKD can result profound changes biosynthetic pattern, structure colon. Increases bacteria that produce urease, uricase, p-cresol- indole-forming enzymes depletion possess short chain fatty acid forming described human animal models. Disruption epithelial tight junction different models reported is largely due conversion luminal urea ammonia by urease possessing bacteria. Together, these contribute pathogenesis systemic inflammation toxicity allowing translocation endotoxin microbial fragments into circulation. Additionally, are main source several well-known pro-inflammatory toxins such as indoxyl sulfate, P-cresol sulfate. This review intended provide an overview intestinal barrier their toxicity.