Changes in cell populations and immunoglobulin-producing cells in the spleens of mice infected with Trypanosoma cruzi: Correlations with parasite-specific antibody response

摘要: Abstract Infection of mice with Trypanosoma cruzi elicits the production parasite-specific antibodies which reach high levels and remain elevated for at least 105 days infection. The more susceptible C3H(He) mouse actually has a higher level “natural” T. but may show greater lag time in response to infection than resistant C57BL/6 mouse. Comparison kinetics antibody against numbers immunoglobulin-producing cells spleen during course suggests that large number are probably producing directed parasite not result an exhaustive polyclonal B-cell activation. Cell change dramatically both total percentage different cell types cruzi. T remains relatively unchanged throughout strains tested Ig-positive decrease markedly acute phase while macrophage increase up sixfold. proportions B cells, macrophages return near normal values by