Targeting the Transforming Growth Factor-β Signaling Pathway in Human Cancer
作者： Nagathihalli S Nagaraj , Pran K Datta
DOI: 10.1517/13543780903382609
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摘要: The transforming growth factor-ss (TGF-beta) signaling pathway plays a pivotal role in diverse cellular processes. TGF-beta switches its from tumor suppressor normal or dysplastic cells to promoter advanced cancers. It is widely believed that the Smad-dependent involved tumor-suppressive functions, whereas activation of Smad-independent pathways, coupled with loss tumor-suppressor functions TGF-beta, important for pro-oncogenic functions. has been considered useful therapeutic target. discovery oncogenic actions generated great deal enthusiasm developing inhibitors treatment cancer. challenge identify group patients where targeted tumors are not only refractory TGF-beta-induced but also responsive tumor-promoting effects TGF-beta. inhibitors, including small and large molecules, have now entered clinical trials. Preclinical studies these shown promise variety different models. Here, we focus on mechanisms specific targets critical effectors progression invasion. This report examines intervention TGF-ss human
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