Propofol does not ameliorate cerebral venous oxyhemoglobin desaturation during hypothermic cardiopulmonary bypass

摘要: Reductions in cerebral venous oxyhemoglobin saturation (Sjo 2 ) occur during the rewarming phase of hypothermic cardiopulmonary bypass (CPB). We prospectively investigated effects propofol on these reductions Sjo <50%). Fiberoptic jugular bulb catheters were inserted 30 patients undergoing coronary artery grafting. Patients randomly allocated to a test or control group. Test group (n = 15) received IV infusion titrated electroencephalographic burst suppression CPB. No significant differences <50% found between groups either by blood sampling and bench oximetry fiberoptic oximetry. The arteriovenous difference lactate concentration became negative 59 120 samples. Propofol was associated with an increased incidence hypotension (mean arterial pressure <50 mm Hg) (P 0.023), requirement for vasoconstrictor therapy 0.025), increases oxygen index < 0.01). Propofol, when administered doses that produce suppression, does not attenuate frequency extent below 50% from However, it is increase anaerobic metabolism. Implications: may be related brain injury. When sufficient did such saturation.