Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction.

摘要: Abstract Background The purpose of this study was to examine the comparative effects propofol and fentanyl on cerebral oxygenation during normothermic cardiopulmonary bypass postoperative cognitive dysfunction. Methods One hundred eighty patients scheduled for elective coronary artery grafting were randomly divided into two groups: group (n = 90) 90). After induction anesthesia, a fiberoptic oximetry oxygen saturation catheter inserted right jugular bulb monitor venous hemoglobin continuously. Hemodynamic measurements arterial blood gases measured at seven time points. All underwent battery neurologic neuropsychological tests day before operation 6 months after operation. Results Cerebral desaturation (defined as value less than 50%) more frequent in group. (duration when ratio total differed significantly from those (fentanyl group: 27 ± 14 minutes, 20% 9%; 18 11 14% 7%, respectively, p Conclusions Propofol preserved state estimated by compared with However, did not affect