The multifaceted regulation and functions of PKM2 in tumor progression.
作者： Zongwei Li , Peng Yang , Zhuoyu Li
DOI: 10.1016/J.BBCAN.2014.07.008
关键词:
摘要: Tumor cells undergo metabolic rewiring from oxidative phosphorylation towards aerobic glycolysis to maintain the increased anabolic requirements for cell proliferation. It is widely accepted that specific expression of the M2 type pyruvate kinase (PKM2) in tumor cells contributes to this aerobic glycolysis phenotype. To date, researchers have uncovered myriad forms of functional regulation for PKM2, which confers a growth advantage on the tumor cells to enable them to adapt to various microenvironmental signals. Here the …
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