Epidemiology and Pathogenesis of Hemorrhagic Fever with Renal Syndrome

摘要: The outbreak of deadly hantavirus pulmonary syndrome (HPS) in the United States 1993 (CDC., 1993) changed concept hemorrhagic fever with renal (HFRS) (WHO, 1983) because clinical manifestations this newly described infection (Duchin et al., 1994) are quite different from known typical forms HFRS caused by Hantaan, Seoul, and Puumala viruses it occurred States, where disease had not been to exist previously. Recent data on show that occurs Old World HPS, novel hantaviruses, New World. Epidemiological studies progressed rapidly after discovery Hantaan virus, etiologic agent Korean (Lee Lee, 1976; Lee 1978) through seroepidemiologic surveys infections humans animals. It was long believed only certain limited rural areas Eurasia, such as Korea, China, Far East Russia, Northern Europe (Lee, 1982). findings van der Groen, 1989; 1990b), however, have shown patients can be found but also urban cities many parts world.