Glutamatergic agents for OCD and related disorders

摘要: Pharmacotherapy remains inadequate for many patients with OCD; there is an urgent need alternative pharmacological strategies. Convergent evidence suggests imbalance in glutamate, the brain's primary excitatory neurotransmitter, some patients. This has motivated interest glutamate modulators who are unresponsive to standard pharmacotherapeutic approaches. While no modulator can be considered proven as efficacious treatment of OCD, promising suggestions benefit have been reported memantine and riluzole. The thinner N-acetylcysteine, but this agent's low cost benign side effect profile make it a reasonable consideration certain Intriguing research on D-cycloserine ketamine suggest potential well. It notable that these agents all work by different, cases opposite, mechanisms; we much learn about role dysregulation etiology its treatment.