Effectiveness of radiation therapy in GIST: A case report

摘要: Over the last decade, gastrointestinal stromal tumor (GIST) became most commonly diagnosed mesenchymal of tract (2,3)Population-based studies suggest an annual incidence between 11 and 14.5 per million a prevalence 129 (8). The immunohistochemistry GIST shows presence cellsurface antigen CD117 (KIT), which represents defining characteristic (4-7). Immunostaining is essential to differentiate GISTs from other more rare tumors. Differential diagnosis includes leiomyosarcomas, leiomyomas schwannomas It believed that arise neoplastic transformation intestinal pacemaker cells known as interstitial Cajal (ICC) (6,9). Prior 2002, only available therapeutic option for patients with localized was surgical resection (10). Unfortunately, even when excised in negative margins, recurrence rate lesions larger than 3 cm found be significant. Introduction first tyrosine k inase inhibitor, imatinib mesylate, has dramatical ly changed management options avai lable (11). role radiation therapy treatment not been documented (12). In past, clinicians were reluctant use due concerns over dose received by normal tissues, mostly potential toxicity. As such, uti l ized rarely, pall iation purposes (13). this report, we describe successful intensity modulated treat individual large intra-abdominal (Figure 1), deemed unresectable. An initial attempt at systemic tolerated patient did produce significant response.