Effect of Phencyclidine on Neuregulin Expression, Cortical Interneurons, and Redox Dysregulation
作者： Nataša Petronijević , Nevena V. Radonjić
DOI: 10.1016/B978-0-12-800212-4.00057-1
关键词:
摘要: Abstract Phencyclidine (PCP), a dissociative anesthetic often abused as hallucinogen, can induce schizophrenia-like psychosis, including positive and negative symptoms cognitive dysfunction. PCP is noncompetitive antagonist of the N-methyl- d -aspartate receptor (NMDAR). NMDAR hypofunction has been proposed to be critical component pathophysiology schizophrenia, promoting deficits in gamma-aminobutyric acid (GABA)ergic signaling. Perinatal administration rodents represents one actual animal models schizophrenia. Here, we explore acute long-term effects perinatal on expression neuregulin-1, putative risk gene described Furthermore, treatment density different subclasses GABAergic cortical interneurons, redox homeostasis, susceptibility interneurons harmful free radicals are discussed.
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