Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity
作者： Tobias B Dansen , Lydia M M Smits , Miranda H van Triest , Peter L J de Keizer , Dik van Leenen
DOI: 10.1038/NCHEMBIO.194
关键词:
摘要: Cellular damage invoked by reactive oxygen species plays a key role in the pathobiology of cancer and aging. Forkhead box class O (FoxO) transcription factors are involved various cellular processes including cell cycle regulation, apoptosis resistance to species, studies animal models have shown that these vital importance tumor suppression, stem maintenance lifespan extension. Here we report activity FoxO human cells is directly regulated redox state through unique mechanism signal transduction. We show induce formation cysteine-thiol disulfide–dependent complexes p300/CBP acetyltransferase, modulation biological p300/CBP-mediated acetylation fully dependent on this redox-dependent complex. These findings link status longevity protein FoxO.
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