Hypertension in the elderly: the role of calcium antagonists.

摘要: Calcium antagonists have a spectrum of actions that opposes many the pathophysiological abnormalities found in hypertension old age. There is good evidence these drugs reduce blood pressure effectively elderly. no from controlled studies to indicate they are more effective elderly than young subjects. equally convincing age an independent predictor hypotensive efficacy calcium channel antagonists, after effect pretreatment and random variation been taken into account. comparing with other classes antihypertensive age, there any one group superior this group. demonstrating beneficial on morbidity mortality associated elderly, or indeed Side effects common subjects usually mild. Overall, valuable appropriate for treatment They may be particularly useful treating conditions occur increased frequency such as peripheral vascular disease, ischemic heart cardiac arrhythmias, obstructive airways disease. Since plasma concentrations elevated patients due altered pharmacokinetics, therapy should started low doses gradually.