SLE-Associated Tests

作者: Maureen McMahon , Kenneth Kalunian

DOI: 10.1016/B978-012455900-4/50279-8

关键词:

摘要: A diagnosis of systemic lupus erythematosus (SLE) is likely if four eleven “the American College Rheumatology criteria for SLE” are met, which given in a table this chapter. The detection autoantibodies patients not only useful establishing SLE, but may also reflect disease activity, correlate with organ involvement, and predict relapse. It important to recognize, however, that no one test or panel can perform all these activities, as increases the specificity usually correspond decreases sensitivity. Additionally, clinical features SLE mediated by antibodies. most common screening immunofluorescence on rodent liver human epithelial (Hep-2) tissue, although enzyme-linked immunosorbent assays (ELISA) available. In selected populations antinuclear antibodies (ANAs) highly sensitive when Hep-2 cells used, over 98 per cent who fulfill have positive test. .

参考文章(143)
V J Gauthier, M Mannik, A small proportion of cationic antibodies in immune complexes is sufficient to mediate their deposition in glomeruli. Journal of Immunology. ,vol. 145, pp. 3348- 3352 ,(1990)
M. Gioud, M. Ait Kaci, J. C. Monier, Histone antibodies in systemic lupus erythematosus. A possible diagnostic tool. Arthritis & Rheumatism. ,vol. 25, pp. 407- 413 ,(1982) , 10.1002/ART.1780250408
Thomas A. Fleisher, Introduction to Diagnostic Laboratory Immunology JAMA: The Journal of the American Medical Association. ,vol. 278, pp. 1823- 1834 ,(1997) , 10.1001/JAMA.1997.03550220029006
Michele E. Kemp, John P. Atkinson, Verna M. Skanes, R. Paul Levine, David D. Chaplin, Deletion of C4A genes in patients with systemic lupus erythematosus Arthritis & Rheumatism. ,vol. 30, pp. 1015- 1022 ,(1987) , 10.1002/ART.1780300908
Thomas Exner, John McRea, Studies on the relationship between 'antiphospholipid' antibodies and the lupus anticoagulant. Blood Coagulation & Fibrinolysis. ,vol. 1, pp. 17- 21 ,(1990) , 10.1097/00001721-199003000-00004
DONATO ALARCÓN-SEGOVIA, MARGARITA DELEZÉ, CARMEN V. ORIA, JORGE SÁNCHEZ-GUERRERO, Luis GÓMEZ-PACHECO, JAVIER CABIEDES, LUIS FERNÁNDEZ, SERGIO PONCE DE LEÓN, Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine. ,vol. 68, pp. 353- ,(1989) , 10.1097/00005792-198911000-00003