Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii.
作者： Corneliu Ovidiu Vrancianu , Irina Gheorghe , Ilda Barbu Czobor , Mariana Carmen Chifiriuc
DOI: 10.3390/MICROORGANISMS8060935
关键词:
摘要: Antibiotic resistance is one of the biggest challenges for clinical sector and industry, environment societal development. One most important pathogens responsible severe nosocomial infections Acinetobacter baumannii, a Gram-negative bacterium from Moraxellaceae family, due to its various mechanisms, such as β-lactamases production, efflux pumps, decreased membrane permeability altered target site antibiotic. The enormous adaptive capacity A. baumannii acquisition transfer antibiotic determinants contribute ineffectiveness current therapeutic strategies, including last-line or combined therapy. In this review, we will present an update profiles underlying mechanisms in progress developing innovative strategies combating multidrug-resistant (MDRAB) infections.
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