Drug Repurposing of Metabolic Agents in Malignant Glioma

摘要: Gliomas are highly invasive brain tumors with short patient survival. One major pathogenic factor is aberrant tumor metabolism, which may be targeted different specific and unspecific agents. Drug repurposing of increasing interest in glioma research. Drugs interfering the patient’s metabolism also influence metabolism. In this review, we outline definitions methods for drug repurposing. Furthermore, give insights into important candidates a metabolic repurposing, namely metformin, statins, non-steroidal anti-inflammatory drugs, disulfiram lonidamine. Advantages pitfalls will finally discussed.