Repositioning Lidocaine as an Anticancer Drug: The Role Beyond Anesthesia.

作者: Daipeng Zhou , Lei Wang , Qingbin Cui , Ryma Iftikhar , Yanfei Xia

DOI: 10.3389/FCELL.2020.00565

关键词: Drug discoveryCancerMetastasisCancer cellDrug repositioningLidocaineMedicineBioinformaticsClinical trialChemosensitizer

摘要: … Lidocaine (0.5, 2, and 8 mM, which were determined by MTT and BrdU assays) was found to suppress the expression of GOLPH2 in NSCLC A549 cells, leading to cell cycle arrest at …

参考文章(136)
Amer M Alanazi, Mumtaz Jabeen, Ali Sabir Abdelhameed, Azmat Ali Khan, Arun Chauhan, Design, synthesis and in vitro anticancer evaluation of a stearic acid-based ester conjugate. Anticancer Research. ,vol. 33, pp. 2517- 2524 ,(2013)
Chiara Riganti, Enrico Mini, Stefania Nobili, Editorial: Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues Frontiers in Oncology. ,vol. 5, pp. 105- 105 ,(2015) , 10.3389/FONC.2015.00105
Zacharenia Nikitaki, Ioannis Michalopoulos, Alexandros G Georgakilas, Molecular inhibitors of DNA repair: searching for the ultimate tumor killing weapon Future Medicinal Chemistry. ,vol. 7, pp. 1543- 1558 ,(2015) , 10.4155/FMC.15.95
Chang Young Lee, Hyo Sup Shim, Seokkee Lee, Jin Gu Lee, Dae Joon Kim, Kyung Young Chung, Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer Journal of Cardiothoracic Surgery. ,vol. 10, pp. 44- 44 ,(2015) , 10.1186/S13019-015-0248-3
Barbara Pavan, Guglielmo Paganetto, Damiano Rossi, Alessandro Dalpiaz, Multidrug resistance in cancer or inefficacy of neuroactive agents: innovative strategies to inhibit or circumvent the active efflux transporters selectively Drug Discovery Today. ,vol. 19, pp. 1563- 1571 ,(2014) , 10.1016/J.DRUDIS.2014.06.004
Hugo Cesar Pinto Marques Caracas, José Vinícius Bolognesi Maciel, Patrícia Machado Rodrigues e Silva Martins, Margareth Maria Gomes de Souza, Lucianne Cople Maia, The use of lidocaine as an anti-inflammatory substance: A systematic review Journal of Dentistry. ,vol. 37, pp. 93- 97 ,(2009) , 10.1016/J.JDENT.2008.10.005
Azmat Ali Khan, Mahboob Alam, Saba Tufail, Jamal Mustafa, Mohammad Owais, None, Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: an in vitro study. European Journal of Medicinal Chemistry. ,vol. 46, pp. 4878- 4886 ,(2011) , 10.1016/J.EJMECH.2011.07.044
Carey K. Anders, Rebecca Johnson, Jennifer Litton, Marianne Phillips, Archie Bleyer, Breast Cancer Before Age 40 Years Seminars in Oncology. ,vol. 36, pp. 237- 249 ,(2009) , 10.1053/J.SEMINONCOL.2009.03.001
Ru Jiang, Oleksandr Ekshyyan, Tara Moore-Medlin, Xiaohua Rong, Sean Nathan, Xin Gu, Fleurette Abreo, Eben L. Rosenthal, Mingxia Shi, Joseph T. Guidry, Rona S. Scott, Lindsey M. Hutt-Fletcher, Cherie-Ann O. Nathan, Association between human papilloma virus/Epstein-Barr virus coinfection and oral carcinogenesis. Journal of Oral Pathology & Medicine. ,vol. 44, pp. 28- 36 ,(2015) , 10.1111/JOP.12221