The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor.
作者： Masahiro Sakaguchi , Yoshihiro Kuroda , Munetaka Hirose
DOI: 10.1213/01.ANE.0000198330.84341.35
关键词:
摘要: Local anesthetics suppress proliferation in several cancer cells. The mechanism of the suppression, however, is unknown. Our previous study shows that lidocaine, at level tissue concentration under topical or local administration, has a direct inhibitory effect on activity epidermal growth factor receptor (EGFR), which potential target for antiproliferation Therefore, we hypothesized lidocaine would cells through inhibition EGFR activity. We investigated effects (40-4000 microM) human tongue cell line, CAL27, high expression, and also examined (EGF)-stimulated autophosphorylation CAL27 A clinical (400 suppressed both serum-induced EGF-induced inhibited EGF-stimulated tyrosine kinase without cytotoxicity. larger (4000 showed cytotoxicity with an antiproliferative effect. suggest one mechanisms Lidocaine administered topically within oral cavity pain relief may
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