Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives.
作者： Leila Tabrizi , Patrick McArdle , Andrea Erxleben , Hossein Chiniforoshan
DOI: 10.1016/J.EJMECH.2015.09.018
关键词:
摘要: Metal complexes of the type [Ni(LC)2(X)2], 1 and 2, [Co(LC)2(X)2], 3 4 (LC: lidocaine, X = dca (dicyanamide), 3, NCS(-), 2 4) have been synthesized characterized. The geometries 1-4 were confirmed by single crystal X-ray crystallography. are water soluble stable in aqueous solution. interaction with calf thymus DNA (CT DNA) bovine serum albumin (BSA) was investigated using UV-visible fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that cleave pUC19 plasmid DNA. vitro free radical scavenging, antimicrobial activity cytotoxic potential all examined.
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