New water-soluble palladium(II) complexes of lidocaine and phenylcyanamide derivative ligands: cytotoxicity and cellular response mechanisms.
作者： Leila Tabrizi , Hossein Chiniforoshan
DOI: 10.1007/S10637-016-0393-0
关键词: Cytotoxicity 、 Intracellular 、 Cisplatin 、 Cancer cell 、 Reactive oxygen species 、 Chemistry 、 Adenocarcinoma 、 Stereochemistry 、 Apoptosis 、 In vitro
摘要: Three new palladium(II) complexes of lidocaine and phenylcyanamide derivative ligands formula K[Pd(2,6-Me2pcyd)2(LC)], 1, K[Pd(2,6-Et2pcyd)2(LC)], 2, K[Pd(2,6-Cl2pcyd)2(LC)], 3 (LC: lidocaine, 2,6-Me2pcyd: 2,6-dimethyl phenylcyanamide, 2,6-Et2pcyd: 2,6-diethyl 2,6-Cl2pcyd: 2,6-dichloro phenylcyanamide) have been synthesized fully characterized. The 1–3 revealed a significant in vitro antiproliferative activity against human ovarian carcinoma (A2780), colorectal adenocarcinoma (HT29), breast (MCF-7), liver hepatocellular (HepG-2) lung (A549) cancer cell lines. All the are more active than cisplatin follow trend 2 > 1 3. Mechanistic studies showed that cytotoxicity Pd(II) is mainly consistent with their ability to accumulate into cells increase intracellular basal reactive oxygen species levels, which consequently results loss mitochondrial membrane potential apoptosis induction.
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