The first dinuclear copper(II) and zinc(II) complexes containing novel Bis-TACN: syntheses, structures, and DNA cleavage activities
作者： Jing Qian , Wen Gu , Hui Liu , Fengxian Gao , Li Feng
DOI: 10.1039/B615148E
关键词:
摘要: Two novel binuclear complexes [Cu2(L)]·(ClO4)2 (1) and [Zn2(L)]·(ClO4)2 (2) were synthesized crystallographically characterized {L = 14,54-dimethyl-12,52-dihydroxy-1(1,3),5(1,3)-dibenzene-3(1,4),7(1,4)-di-1,4,7-triazacyclononane}. The cation [Cu2(L)]2+ structure of 1 is similar to that [Zn2(L)]2+ 2. central ion bridged by the di-phenoxo L lies in a close perfect square pyramidal geometry. 2 crystallize triclinic space group P. two effectively promote cleavage plasmid DNA presence activating agents at physiological pH temperature. pseudo-Michaelis–Menten kinetic parameters kcat 1.61 h−1, Km 1.35 × 10−5 M for complex mercaptoethanol; 2.48 5.5 10−5M hydrogen peroxide obtained. mechanism was studied adding standard radical scavengers. reaction Zn(II)/H2O2 system hydrolytic mechanism.
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