Dinuclear cadmium indomethacin and Lawsone complexes: synthesis, crystal structures, antiproliferative and biological evaluations
作者： Leila Tabrizi , Reza Golbang , Hamid Sadeghi , Hossein Chiniforoshan , Patrick Mcardle
DOI: 10.1080/00958972.2016.1223845
关键词: Antimicrobial 、 Fluorescence 、 Cadmium 、 Bovine serum albumin 、 Chemistry 、 Lawsone 、 DNA 、 Crystal structure 、 Stereochemistry 、 Cytotoxicity
摘要: AbstractThe synthesis and structural characterizations of Cd(II) indomethacin (Indo) Lawsone (Law) complexes, K2[Cd2(Indo)4(SCN)2], 1 [Cd2(Law)4(phen)2]·4CH3OH, 2 (SCN = thiocyanate, phen = 1,10-phenanthroline), have been studied. The complexes are dimeric, structurally characterized by spectral (IR, TOF-Mass) X-ray crystallography. interaction ligands, with calf thymus DNA bovine serum albumin were investigated using UV–visible fluorescence spectrophotometric methods. in vitro cytotoxicity was examined against promyelocytic leukemia (HL-60), colon (HCT-8), brain (SF-295), melanoma (MDA-MB-435) cancer cell lines. Moreover, the antimicrobial activity different strains pathogenic bacteria tested.
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