A novel binuclear hydrazone-based Cd(II) complex is a strong pro-apoptotic inducer with significant activity against 2D and 3D pancreatic cancer stem cells.

作者: Snežana Bjelogrlić , Tamara R. Todorović , Ilija Cvijetić , Marko V. Rodić , Miroslava Vujčić

DOI: 10.1016/J.JINORGBIO.2018.10.002

关键词:

摘要: … adenocarcinoma cells (MCF-7) and pancreatic AsPC-1 cancer stem cells (CSCs). While apoptosis … activity of 1 as a drug candidate for the treatment of highly resistant pancreatic cancer. …

参考文章(157)
Snežana Bjelogrlić, Tamara Todorović, Alessia Bacchi, Manja Zec, Dušan Sladić, Tatjana Srdić-Rajić, Dušanka Radanović, Siniša Radulović, Giancarlo Pelizzi, Katarina Anđelković, Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. Journal of Inorganic Biochemistry. ,vol. 104, pp. 673- 682 ,(2010) , 10.1016/J.JINORGBIO.2010.02.009
Fazlul H. Sarkar, Dejuan Kong, Yiwei Li, Zhiwei Wang, Pancreatic cancer stem cells and EMT in drug resistance and metastasis Minerva Chirurgica. ,vol. 64, pp. 489- 500 ,(2009)
M. Tofazzal H. Tarafder, A. Manaf Ali, M. Suhaimi Elias, Karen A. Crouse, Sidik Silong, Coordination chemistry and biological activity of bidentate and quadridentate nitrogen–sulfur donor ligands and their complexes Transition Metal Chemistry. ,vol. 25, pp. 706- 710 ,(2000) , 10.1023/A:1007069601569
G. W. A. Dummer, J. Mackenzie Robertson, Medical electronic laboratory equipment 1967-68 Pergamon Press. ,(1967)
Larry W. Oberley, Marilyn M. Hinkhouse, Frederick E. Domann, Christine Weydert, Joseph J. Cullen, Justine Ritchie, Douglas Spitz, The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma. Cancer Research. ,vol. 63, pp. 1297- 1303 ,(2003)
Marco Borsari, Cadmium: Coordination Chemistry Encyclopedia of Inorganic and Bioinorganic Chemistry. pp. 1- 16 ,(2014) , 10.1002/9781119951438.EIBC2261
Jin'an Zhao, Kun Peng, Yan Guo, Jin Zhang, Shufang Chen, Jiyong Hu, Photoluminescent and cytotoxic properties of multinuclear complexes and multinuclear-based polymers with group 12 metals and a tripodal ligand New Journal of Chemistry. ,vol. 39, pp. 6016- 6024 ,(2015) , 10.1039/C5NJ00222B
Tamara Todorović, Sonja Grubišić, Matej Pregelj, Marko Jagodič, Sonja Misirlić-Denčić, Marija Dulović, Ivanka Marković, Olivera Klisurić, Aleksandar Malešević, Dragana Mitić, Katarina Anđelković, Nenad Filipović, Structural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear CuII Complexes with Bidentate N‐Heteroaromatic Schiff Base Ligands European Journal of Inorganic Chemistry. ,vol. 2015, pp. 3921- 3931 ,(2015) , 10.1002/EJIC.201500349
Nenad R. Filipović, Snežana Bjelogrlić, Aleksandar Marinković, Tatjana Ž. Verbić, Ilija N. Cvijetić, Milan Senćanski, Marko Rodić, Miroslava Vujčić, Dušan Sladić, Zlatko Striković, Tamara R. Todorović, Christian D. Muller, Zn(ii) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction RSC Advances. ,vol. 5, pp. 95191- 95211 ,(2015) , 10.1039/C5RA19849F