Regulation of Follicular Dendritic Cell Networks by Activated T Cells: The Role of CD137 Signaling

摘要: B cells, but not T are considered to be important for the formation of follicular dendritic cell (FDC) clusters. Stimulation with agonist mAbs against CD137 (4-1BB), a TNFR family member primarily expressed on activated was effective in promoting responses, paradoxically suppressed T-dependent humoral immunity and autoantibody production autoimmune disease models. Our present study shows that agonistic anti-CD137 treatment activates resulting diminished FDC networks follicles, which components immune responses both before after initiation an response. Pretreatment secondary immunization inhibited memory Ab responses. Interestingly, costimulation-induced diminishment is dependent. In addition, CD4 + CD8 cells recruited into area able regulate FDCs by costimulation through direct or indirect mechanism. These studies have revealed previously unappreciated role regulation networks.