作者: Yukako Okazaki , Tetsuyuki Katayama
DOI: 10.1016/J.NUTRES.2019.11.010
关键词:
摘要: Phytic acid (PA) or myoinositol intake was recently reported by our group to suppress hepatic lipogenic gene expression and modulate gut microbiota in rats fed a high-sucrose diet (HSC). The aim of this study investigate the effect PA dietary fat level on fatty liver an HSC diet. Male Sprague-Dawley were high-fat (HF), low-fat (LF), with without 1.02% sodium for 12 days. Hepatic lipid levels, enzyme activity, enzymes transcriptional factors related metabolism, cecal organic acids, fecal evaluated. depressed total triglyceride levels; reduced activity enzymes; elevated proportion Lactobacillus spp; increased succinate LF HF diet, when compared carnitine palmitoyl-transferase 1a cAMP-responsive element binding protein 3-like 3; proportions spp Bifidobacterium spp. In groups, did not affect associated metabolism microbiota. conclusion, could change and, turn, alter degree nutritional importance