Understanding tissue morphology: model repurposing using the CoSMoS process

摘要: We present CoSMoS as a way of structuring thinking on how to reuse parts an existing model and simulation in new its implementation. provides lens through which consider, post-implementation, the assumptions made during design implementation software physical interactions formation vascular structures from endothelial cells. show abstract can be adapted for different problem: growth cancer cells under varying environmental perturbations. identify changes that must adapt context, along with gaps our knowledge domain filled by wet-lab experimentation when recalibrating model. Through parameter exploration, we parameters are critical dynamic structure modelled tissue, calibrate these using series vitro experiments. Drawing inspiration project structure, maintain confidence repurposed model, achieve satisfactory degree within silico experimental system.