Elevated Levels of Systemic Pentraxin 3 Are Associated With Thin-Cap Fibroatheroma in Coronary Culprit Lesions: Assessment by Optical Coherence Tomography and Intravascular Ultrasound
作者： Seiji Koga , Satoshi Ikeda , Takeo Yoshida , Tomoo Nakata , Masayoshi Takeno
DOI: 10.1016/J.JCIN.2013.04.024
关键词:
摘要: Objectives This study sought to determine whether systemic levels of pentraxin 3 (PTX3), a novel inflammatory marker, are associated with thin-cap fibroatheroma (TCFA). Background Biomarkers predicting the presence TCFA in vivo have not been established. Methods We evaluated 75 patients (stable angina pectoris, n = 47; acute coronary syndrome, 28) de novo culprit lesions who were examined by optical coherence tomography and intravascular ultrasound. defined as lipid-rich plaque fibrous cap Results Thirty-eight 37 without TCFA, respectively, identified. Levels PTX3 significantly higher than those (p 3.24 ng/ml could predict 84% sensitivity 86% specificity. Conclusions Higher TCFA. Systemic comprise useful marker that reflects vulnerability.
nagasaki-u.ac.jp
elsevier.com参考文章(28)
Koji Kato, Taishi Yonetsu, Soo-Joong Kim, Lei Xing, Hang Lee, Iris McNulty, Robert W. Yeh, Rahul Sakhuja, Shaosong Zhang, Shiro Uemura, Bo Yu, Kyoichi Mizuno, Ik-Kyung Jang, Comparison of Nonculprit Coronary Plaque Characteristics Between Patients With and Without Diabetes JACC: Cardiovascular Interventions. ,vol. 5, pp. 1150- 1158 ,(2012) , 10.1016/J.JCIN.2012.06.019
Christopher K. Glass, Joseph L. Witztum, Atherosclerosis: The Road Ahead Cell. ,vol. 104, pp. 503- 516 ,(2001) , 10.1016/S0092-8674(01)00238-0
Guillermo J. Tearney, Evelyn Regar, Takashi Akasaka, Tom Adriaenssens, Peter Barlis, Hiram G. Bezerra, Brett Bouma, Nico Bruining, Jin-man Cho, Saqib Chowdhary, Marco A. Costa, Ranil de Silva, Jouke Dijkstra, Carlo Di Mario, Darius Dudeck, Erlin Falk, Marc D. Feldman, Peter Fitzgerald, Hector Garcia, Nieves Gonzalo, Juan F. Granada, Giulio Guagliumi, Niels R. Holm, Yasuhiro Honda, Fumiaki Ikeno, Masanori Kawasaki, Janusz Kochman, Lukasz Koltowski, Takashi Kubo, Teruyoshi Kume, Hiroyuki Kyono, Cheung Chi Simon Lam, Guy Lamouche, David P. Lee, Martin B. Leon, Akiko Maehara, Olivia Manfrini, Gary S. Mintz, Kyiouchi Mizuno, Marie-angéle Morel, Seemantini Nadkarni, Hiroyuki Okura, Hiromasa Otake, Arkadiusz Pietrasik, Francesco Prati, Lorenz Räber, Maria D. Radu, Johannes Rieber, Maria Riga, Andrew Rollins, Mireille Rosenberg, Vasile Sirbu, Patrick W.J.C. Serruys, Kenei Shimada, Toshiro Shinke, Junya Shite, Eliot Siegel, Shinjo Sonada, Melissa Suter, Shigeho Takarada, Atsushi Tanaka, Mitsuyasu Terashima, Thim Troels, Shiro Uemura, Giovanni J. Ughi, Heleen M.M. van Beusekom, Antonius F.W. van der Steen, Gerrit-Ann van Es, Gijs van Soest, Renu Virmani, Sergio Waxman, Neil J. Weissman, Giora Weisz, Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. Journal of the American College of Cardiology. ,vol. 59, pp. 1058- 1072 ,(2012) , 10.1016/J.JACC.2011.09.079
Giuseppe Danilo Norata, Patrizia Marchesi, Vivek Krishna Pulakazhi Venu, Fabio Pasqualini, Achille Anselmo, Federica Moalli, Irene Pizzitola, Cecilia Garlanda, Alberto Mantovani, Alberico Luigi Catapano, None, Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis Circulation. ,vol. 120, pp. 699- 708 ,(2009) , 10.1161/CIRCULATIONAHA.108.806547
Takahiro Sawada, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Ken-ichi Hirata, Low plasma adiponectin levels are associated with presence of thin-cap fibroatheroma in men with stable coronary artery disease International Journal of Cardiology. ,vol. 142, pp. 250- 256 ,(2010) , 10.1016/J.IJCARD.2008.12.216
David Vancraeynest, Agnes Pasquet, Véronique Roelants, Bernhard L. Gerber, Jean-Louis J. Vanoverschelde, Imaging the vulnerable plaque. Journal of the American College of Cardiology. ,vol. 57, pp. 1961- 1979 ,(2011) , 10.1016/J.JACC.2011.02.018
Manuela Nebuloni, Fabio Pasqualini, Pietro Zerbi, Eleonora Lauri, Alberto Mantovani, Luca Vago, Cecilia Garlanda, PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis Cardiovascular Pathology. ,vol. 20, ,(2011) , 10.1016/J.CARPATH.2010.02.005
Giuseppe Peri, Martino Introna, Domenico Corradi, Giuseppe Iacuitti, Stefano Signorini, Fausto Avanzini, Fabrizio Pizzetti, Aldo P. Maggioni, Tiziano Moccetti, Marco Metra, Livio Dei Cas, Pietro Ghezzi, Jean D. Sipe, Gianpietro Re, Giorgio Olivetti, Alberto Mantovani, Roberto Latini, PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans Circulation. ,vol. 102, pp. 636- 641 ,(2000) , 10.1161/01.CIR.102.6.636
Ruth Dubin, Yongmei Li, Joachim H. Ix, Michael G. Shlipak, Mary Whooley, Carmen A. Peralta, Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: Data from the Heart and Soul Study American Heart Journal. ,vol. 163, pp. 274- 279 ,(2012) , 10.1016/J.AHJ.2011.11.007
Michelle A Albert, Paul M Ridker, None, The role of C-reactive protein in cardiovascular disease risk. Current Cardiology Reports. ,vol. 1, pp. 99- 104 ,(1999) , 10.1007/S11886-000-0081-7