Redox-regulated fate of neural stem progenitor cells.

摘要: Abstract Background Accumulated data indicate that self-renewal, multipotency, and differentiation of neural stem cells are under an intrinsic control mediated by alterations in the redox homeostasis. These dynamic changes not only reflect support ongoing metabolic energetic processes, but also serve to coordinate redox-signaling cascades. Controlling particular couples seems have a relevant impact on cell fate decision during development, adult neurogenesis regeneration. Scope review Our own research provided initial evidence for importance NAD + -dependent enzymes decision. In this review, we summarize recent knowledge active role reactive oxygen species, mechanisms plasticity function progenitor focusing NAD(P) /NAD(P)H-mediated processes. Major conclusions The compartmentalized subcellular sources availability oxidizing/reducing molecules microenvironment define specificity regulation modulating delicate balance between stemness progenitors. generalization “reactive species” as well ambiguity their origin might explain diametrically-opposed findings field redox-dependent reflected literature. General significance Increasing temporary spatially defined is high relevance development novel approaches cell-based regeneration nervous tissue various pathological states. This article part special issue entitled Redox de-differentiation.