Temporal profiles of plasma proteome during childhood development
作者： Chih-Wei Liu , Lisa Bramer , Bobbie-Jo Webb-Robertson , Kathleen Waugh , Marian J. Rewers
DOI: 10.1016/J.JPROT.2016.11.016
关键词:
摘要: Abstract Human blood plasma proteome reflects physiological changes associated with a child's development as well of disease states. While age-specific normative values are available for proteins routinely measured in clinical practice, there is paucity comprehensive longitudinal data regarding human during childhood. We applied TMT-10plex isobaric labeling-based quantitative proteomics to longitudinally profile the 10 healthy children their development, each 9 serial time points from 9 months 15 years age. In total, 1828 protein groups were identified at peptide and level false discovery rate 1% least two razor unique peptides. The expression profiles 1747 statistically modeled temporal categorized into 7 different patterns. patterns relative abundance obtained by LC-MS also verified ELISA. To our knowledge, this study represents most profiling date. provide resource reference biomarker studies childhood diseases. Biological significance: A pediatric database neonate adolescence was provided research community. 970 had age-dependent trends, which demonstrated importance identify potential biomarkers specific diseases, requirement strictly age-matched samples cross-sectional population.
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