High Yes-associated protein 1 with concomitant negative LATS1/2 expression is associated with poor prognosis of advanced gastric cancer.
作者： Eojin Kim , Bokyung Ahn , Harim Oh , Yoo Jin Lee , Jeong Hyeon Lee
DOI: 10.1016/J.PATHOL.2019.01.001
关键词:
摘要: Summary The Hippo pathway is a tumour-suppressive and its inactivation known to be associated with progression metastasis of various cancers. LATS1/2 (large tumour suppressor homolog 1 2), YAP1 (Yes-associated protein 1), TEAD4 (TEA domain-containing sequence-specific transcription factors 4) are core components the pathway, their prognostic roles have not yet been studied in advanced gastric cancers (AGCs). A total 318 surgically resected AGCs were retrieved. Immunolabelling for LATS1/2, was compared clinicopathological including patients' survival. High expression identified 108 (34.0%) 131 (41.2%) cases, respectively, 223 (70.1%) cases negative expression. significantly correlated presence perineural invasion (p=0.032). high expressions poor overall survival (p
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