α-Tocopherol-doped irradiated UHMWPE for high fatigue resistance and low wear
作者： Ebru Oral , Keith K Wannomae , Nathaniel Hawkins , William H Harris , Orhun K Muratoglu
DOI: 10.1016/J.BIOMATERIALS.2003.12.048
关键词:
摘要: Abstract Longevity of total joints has been compromised by wear and fatigue ultrahigh molecular weight polyethylene (UHMWPE) components. Crosslinking reduces UHMWPE wear, but combined with postirradiation melting, also its strength, therefore limiting use in high-stress applications. We hypothesized that a lipophilic antioxidant (α-tocopherol, α-T) can protect against oxidation eliminating the need for melting crosslinked improve strength. To test these hypotheses, 65- 100-kGy irradiated, α-T-doped subsequently γ-sterilized were used. (I) irradiated UHMWPEs showed significantly lower levels (0.48±0.25 0.44±0.06) compared to (3.74±0.16) after 5 weeks accelerated aging at 80°C air. (II) Wear rate (1.9±0.5, 0.9±0.1 mg/million cycles (MC) UHMWPE, respectively) comparable irradiated/melted (1.1±0.7 mg/million cycles). (III) The stress intensity factor crack inception (ΔKi) increased upon doping α-T from 0.74 0.87 MPa m1/2 (p
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