Effect of Demographics on Excretion of Key Urinary Factors Related to Kidney Stone Risk

摘要: Objective To investigate the effect of demographics including age and sex on excretion 4 key urinary factors (calcium [Ca], magnesium [Mg], oxalate uric acid [UA]) related to kidney stone risk. Methods Twenty-four–hour urine samples were collected from non-Hispanic white sibships in Rochester, MN. Height, weight, blood pressure, serum creatinine, cystatin C measured. Diet was assessed using Viocare food frequency questionnaire. Effects dietary elements excretions evaluated univariate, multivariate, interaction models that included age, sex, body mass index (BMI). Results Samples available 709 individuals. In multivariate models, a significant predictor all factors, for but UA excretion, creatinine only Ca Mg (P <.05). BMI or weight positively correlated with Mg, oxalate, Use thiazide diuretic (lower) protein (higher) associated whereas higher excretion. Urinary increased animal intake estimated glomerular filtration rate (eGFR) lower concurrent loop use. Significant effects observed use eGFR intake, (P <.05). Conclusion Age influence risk should be taken into account when evaluating patients.