Longitudinal Analysis of Renal Function using ZIP GEE on OLT Transplant Patients Undergoing NAC Prophylaxis

摘要: Organ dysfunction is associated with oxidative stress following Orthotropic Liver Transplant (OLT) surgery. N-Acetyl Cysteine (NAC) an acetylated form of the amino acid cysteine. NAC known to replenish glutathione in bloodstream which helps relieve cell damage caused by stress. was used a placebo controlled study discover its effects on organ OLT A standard treatment, as treat acetaminophen toxicity, treatment during Measures hepatic and renal were recorded at unequally spaced time-points for follow-up time one year. The Generalized Estimating Equation (GEE) approach model continuous responses. Discrete responses are shown follow unique distribution. This distribution accommodated GEE procedure proposed Liang Zeger produce consistent efficient estimates effect NAC. produced contradictory results hypothesized protective against dysfunction. public health relevance this work that if be efficacious respect function, can benefit over six thousand patients each