Lesions of the thalamic reticular nucleus or the basal forebrain impair Pavlovian eyeblink conditioning and attenuate learning-related multiple-unit activity in the mediodorsal nucleus of the thalamus

作者: D. A. Powell , D. A. Powell , Shirley L. Buchanan , Shirley L. Buchanan , Francis M. Beylotte

DOI: 10.3758/BF03327026

关键词:

摘要: Rabbits received ibotenic acid lesions of the thalamic reticular nucleus or basal forebrain, sham lesions, and had multiple-unit recording electrodes implanted in mediodorsal thalamus (MD). Animals were compared on four sessions simple Pavlovian conditioning using a tone conditioned stimulus (CS) periorbital electric shock unconditioned (US). Eyeblink (EB) heart rate (HR) responses recorded, as well activity (MUA) from MD. MD MUA sham-Iesioned animals showed small but consistent increases response to CS. Le­ sions either forebrain decreased magnitude changes recorded impaired acquisition EB (CR). Reticular nucleus, not slightly enhanced HR CR. Since MD's efferent projections are prefrontal cortex, these results support idea that MD, possibly due its forebrain-reticular afferent connections, may participate "response selec­ tion" function cortex. The (MD) is pri­ mary providing inputs cortex (PFC) has historically been implicated many same behavioral functions PFC. Previous stud­ ies our laboratory have indicated ofMD impair ofthe classically eyeblink rabbit and, some extent, bias accompanying decelerations parasympathetic direction (Buchanan & Thompson, 1990). Lesions ofPFC, other hand, dramatically im­ pair bradycardiac (CR), do affect CR Powell, 1982; Pow­ ell, Watson, Maxwell, 1994). Multiple- single-unit PFC also correlated with ex­ pression (Gibbs 1988, 1991; Buchanan, However, such neuronal during classical related expression

参考文章(39)
Philippe Richard, Ivan Urban, A stereotaxic atlas of the New Zealand rabbit's brain ,(1972)
Garrett E. Alexander, Michael D. Crutcher, Mahlon R. DeLong, Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Progress in Brain Research. ,vol. 85, pp. 119- 146 ,(1991) , 10.1016/S0079-6123(08)62678-3
Orrin Devinsky, Martha J. Morrell, Brent A. Vogt, Contributions of anterior cingulate cortex to behaviour. Brain. ,vol. 118, pp. 279- 306 ,(1995) , 10.1093/BRAIN/118.1.279
Y. Tai, H. Yi, I.A. Ilinsky, K. Kultas-Ilinsky, Nucleus reticularis thalami connections with the mediodorsal thalamic nucleus: A light and electron microscopic study in the monkey Brain Research Bulletin. ,vol. 38, pp. 475- 488 ,(1995) , 10.1016/0361-9230(95)02018-M
Karen Watson, D. A. Powell, Brian Maxwell, Involvement of subdivisions of the medial prefrontal cortex in learned cardiac adjustments in rabbits. Behavioral Neuroscience. ,vol. 108, pp. 294- 307 ,(1994) , 10.1037//0735-7044.108.2.294