作者: D. A. Powell , D. A. Powell , Shirley L. Buchanan , Shirley L. Buchanan , Francis M. Beylotte
DOI: 10.3758/BF03327026
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摘要: Rabbits received ibotenic acid lesions of the thalamic reticular nucleus or basal forebrain, sham lesions, and had multiple-unit recording electrodes implanted in mediodorsal thalamus (MD). Animals were compared on four sessions simple Pavlovian conditioning using a tone conditioned stimulus (CS) periorbital electric shock unconditioned (US). Eyeblink (EB) heart rate (HR) responses recorded, as well activity (MUA) from MD. MD MUA sham-Iesioned animals showed small but consistent increases response to CS. Le sions either forebrain decreased magnitude changes recorded impaired acquisition EB (CR). Reticular nucleus, not slightly enhanced HR CR. Since MD's efferent projections are prefrontal cortex, these results support idea that MD, possibly due its forebrain-reticular afferent connections, may participate "response selec tion" function cortex. The (MD) is pri mary providing inputs cortex (PFC) has historically been implicated many same behavioral functions PFC. Previous stud ies our laboratory have indicated ofMD impair ofthe classically eyeblink rabbit and, some extent, bias accompanying decelerations parasympathetic direction (Buchanan & Thompson, 1990). Lesions ofPFC, other hand, dramatically im pair bradycardiac (CR), do affect CR Powell, 1982; Pow ell, Watson, Maxwell, 1994). Multiple- single-unit PFC also correlated with ex pression (Gibbs 1988, 1991; Buchanan, However, such neuronal during classical related expression