S100B in schizophrenia: an update.

摘要: Recent research has supported a potential role of immune pathology in the etiopathogenesis schizophrenic. In CNS various viruses were identified brains schizophrenic patients. Pro-inflammatory cytokines found to be associated with stage disease. Microglial cells reported activated subgroup patients post mortem as well imaging studies. New demonstrated that astrocytes together microglial are major immunocompetent brain and play an important regulation neuronal proliferation differentiation. S100B, calcium binding astrocyte-specific cytokine, presents marker astrocytic activation. Scientific evidence for increased S100B acute schizophrenia is very consistent. The picture not clear regarding subtypes states but persistent negative symptoms or deficit syndrome show constant high concentrations. There association between poor therapeutic response. concentrations appear functionally relevant since they reflected by cognitive performance cross validation other methods make it unlikely findings merely epiphenomenon. These suggest activation might pathogenic factor development schizophrenia.