S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: A morphometric study

摘要: Abstract Objective Several studies have revealed increased S100B levels in peripheral blood and cerebrospinal fluid (CSF) of patients with schizophrenia. In this context, it was postulated that elevated may indicate changes pathophysiological significance to brain tissue general astrocytes particular. However, no histological study has been published on the cellular distribution individuals schizophrenia clarify hypothesis. Methods The cell-density S100B-immunopositive glia analyzed anterior cingulate, dorsolateral prefrontal (DLPF), orbitofrontal, superior temporal cortices/adjacent white matter, pyramidal layer/alveus hippocampus, mediodorsal thalamic nucleus 18 16 matched control subjects. Results Cortical regions contained more group relative controls ( P  = 0.046). This effect caused by paranoid subgroup  = 0.018). Separate analysis matter diagnostic main  = 0.846). (mainly oligodendrocytic) S100B-positive as compared residual  = 0.021). These effects were particularly pronounced DLPF area. Conclusion Our reveals distinct patterns immunoeactive two subtypes. be indicative a heterogenic pathophysiology or compensatory abilities: Astro-/oligodendroglial activation result On contrary, oligodendroglial damage dysfunction, associated release into body fluids.