S100B serum levels and long-term improvement of negative symptoms in patients with schizophrenia.

摘要: S100B, a calcium-binding protein produced by astroglial cells, mediates paracrine and autocrine effects on neurons glial cells. It regulates the balance between proliferation differentiation in cells affecting protective apoptotic mechanisms. Post-mortem studies have demonstrated deficit synapses dendrites brains of schizophrenics. Recent shown increased S100B levels medicated acutely psychotic schizophrenic patients as well unmedicated or drug naive One study reported positive correlation negative symptoms S100B. serum (quantitative immunoassay) psychopathology (Positive Negative Syndrome Scale, PANSS) were examined upon admission after 12 24 weeks standardized treatment 98 chronic with primarily symptoms. Compared to age- sex-matched healthy controls, showed significantly concentrations treatment. High PANSS scores correlated high levels. Regression analysis comparing subscales identified symptomatology predicting factor for is not just elevated during acute stages disease since it remains at least 6 months following an exacerbation. With regard psychopathology, appears be absolute concentration. This might indicate that either promotes mechanisms itself released from astrocytes part attempt repair degenerative destructive process.