Sequencing and phylogenetic analysis of the gp51 gene from Korean bovine leukemia virus isolates

摘要: Bovine Leukemia virus (BLV) infection of cattle has been reported in Korea for more than three decades. However, to date, there have few studies regarding Korean BLV since 1980s. Thus, the purpose this study is perform a diagnosis and molecular characterization strains circulating estimate genetic diversity different genotypes BLV. To investigate distribution variants world assess evolutionary history isolates, comprehensive analysis env gp51 gene was conducted using recent worldwide isolates. The isolates included 50 samples obtained from two farms southeastern 2014. Sequence phylogenetic analyses partial 444-nt fragment sequences complete revealed eight distinct showing geographic world. Most were found belong genotype 1 which major prevailed throughout world, only four one farm classified as 3 related US Japan Analysis amino acids showed several sequence substitutions leader peptide, conformational epitope, neutralizing domain regions. observations suggest possibility affecting on viral infectivity formation. close relationship 3. Further identify necessary with collected nationwide because first report being circulation Korea.