Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites.

摘要: Natural product search is undergoing resurgence upon the discovery of a huge previously unknown potential for secondary metabolite (SM) production hidden in microbial genomes. This also case filamentous fungi, since their genomes contain high number “orphan” SM gene clusters. Recent estimates indicate that only 5% existing fungal species have been described, thus novel metabolites fungi huge. In this context, thriving harsh environments are particular interest they outstanding producers unusual chemical structures. At present, there around 16 from extreme environment-isolated databases. preliminary analysis three these we found several predicted clusters probably involved biosynthesis compounds not yet described. Genome mining strategies allow exploitation information genome sequences new natural compounds. The synergy between and expected abundance promising path to discover as source medically useful drugs.