Anti-inflammatory effects of South American Tanacetum vulgare.
作者： Guillermo R. Schinella , Rosa-María Giner , MaríA Del Carmen Recio , Perla Mordujovich Buschiazzo , José-luis Ríos
DOI: 10.1111/J.2042-7158.1998.TB06924.X
关键词:
摘要: In recent years the role of phenolic compounds and sesquiterpene lactones, particularly parthenolide, in anti-migraine anti-inflammatory effects Tanacetum parthenium (Asteraceae) has attracted much attention. However, closely-related cosmopolitan species T. vulgare remained outside mainstream research this field. After treating aerial parts with dichloromethane methanol, applying conventional column thin-layer chromatographic techniques, it was possible to isolate from moderately lipophilic fractions principles responsible for activity plant against mouse-ear oedema induced by 12-O-tetradecanoylphorbol 13-acetate. These were identified ultraviolet nuclear magnetic resonance spectroscopy as parthenolide (93% inhibition at 0.5 mg/ear, ID50 (dose drug inhibiting 50%) = 0.18 μmol/ear) methoxyflavones jaceosidin (80% 0.50 μmol/ear), eupatorin, chrysoeriol diosmetin. Because molar terms potency nearly three times greater than that most active flavones because is obtained considerably larger amounts, flavonoids must only be partially responsible, a minor extent, observed in-vivo local effect.
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