PtdIns5P: News and views of its appearance, disappearance and deeds
作者： Assia Shisheva
DOI: 10.1016/J.ABB.2013.07.023
关键词:
摘要: Accumulated evidence indicates that PtdIns5P, one of the seven phosphoinositides, found now to be constitutively present in yeast, plants and metazoa, serves as a signaling molecule modulate pleiotropic cellular functions both nucleus cytoplasm. The enzymatic routes biogenesis basal PtdIns5P have remained incompletely understood. role for candidate kinase PIKfyve is principally involved PtdIns(3,5)P2 production, has been questioned. In this review article we scrutinize past obstacles prevented definitive implication biosynthesis from PtdIns focus on recent pharmacological genetic advancements make conclusion well supported. We further summarize our current knowledge diverse stimuli modulating levels, binding partners regulated process, with particular reference available mechanistic insights relevant pathways.
sci-hub.se 参考文章(123)
Sandra Hakim, Micka C. Bertucci, Sarah E. Conduit, David L. Vuong, Christina A. Mitchell, Inositol Polyphosphate Phosphatases in Human Disease Current Topics in Microbiology and Immunology. ,vol. 362, pp. 247- 314 ,(2012) , 10.1007/978-94-007-5025-8_12
Tatiana G. Kutateladze, Molecular Analysis of Protein–Phosphoinositide Interactions Current Topics in Microbiology and Immunology. ,vol. 362, pp. 111- 126 ,(2012) , 10.1007/978-94-007-5025-8_6
Craig C. WHITEFORD, Charles A. BREARLEY, Emin T. ULUG, Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts. Biochemical Journal. ,vol. 323, pp. 597- 601 ,(1997) , 10.1042/BJ3230597
Lucia E. Rameh, Kimberley F. Tolias, Brian C. Duckworth, Lewis C. Cantley, A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Nature. ,vol. 390, pp. 192- 196 ,(1997) , 10.1038/36621
Diego Sbrissa, Ognian C. Ikonomov, Homer Fenner, Assia Shisheva, ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality Journal of Molecular Biology. ,vol. 384, pp. 766- 779 ,(2008) , 10.1016/J.JMB.2008.10.009
J. Zou, J. Marjanovic, M. V. Kisseleva, M. Wilson, P. W. Majerus, Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 16834- 16839 ,(2007) , 10.1073/PNAS.0708189104
Claire Chaussade, Luciano Pirola, Stéphanie Bonnafous, François Blondeau, Stefano Brenz-Verca, Hélène Tronchère, Fiorella Portis, Sandro Rusconi, Bernard Payrastre, Jocelyn Laporte, E Van Obberghen, Expression of Myotubularin by an Adenoviral Vector Demonstrates Its Function as a Phosphatidylinositol 3-Phosphate [PtdIns(3)P] Phosphatase in Muscle Cell Lines: Involvement of PtdIns(3)P in Insulin-Stimulated Glucose Transport Molecular Endocrinology. ,vol. 17, pp. 2448- 2460 ,(2003) , 10.1210/ME.2003-0261
Kartik Narayan, Mark A. Lemmon, Determining selectivity of phosphoinositide-binding domains. Methods. ,vol. 39, pp. 122- 133 ,(2006) , 10.1016/J.YMETH.2006.05.006
Willem-Jan Keune, David R Jones, Yvette Bultsma, Lilly Sommer, Xiao Zhen Zhou, Kun Ping Lu, Nullin Divecha, Regulation of Phosphatidylinositol-5-Phosphate Signaling by Pin1 Determines Sensitivity to Oxidative Stress Science Signaling. ,vol. 5, ,(2012) , 10.1126/SCISIGNAL.2003223
Diego Sbrissa, Ognian C. Ikonomov, Robert Deeb, Assia Shisheva, Phosphatidylinositol 5-Phosphate Biosynthesis Is Linked to PIKfyve and Is Involved in Osmotic Response Pathway in Mammalian Cells Journal of Biological Chemistry. ,vol. 277, pp. 47276- 47284 ,(2002) , 10.1074/JBC.M207576200