MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells.

摘要: The natural killer cell gene complex on human chromosome 12p12-13 encodes several C-type lectin receptor genes expressed by NK cells and other hematopoietic cells. We have identified a novel in this region encoding putative type II transmembrane glycoprotein. product is 54% identical to the rat mast function-associated antigen (MAFA), which inhibits activation IgE. MAFA-like (MAFA-L) MAFA protein are basophils both an immunoreceptor tyrosine-based inhibitory motif cytoplasmic tail, consistent with role basophil activation. Unlike MAFA, expression of MAFA-L not limited basophils. In common also as well monocyte-like cell-line U937. Expression restricted peripheral blood cells, decidual do express MAFA-L. While might similar basophils, types implies additional functions for molecule. presence indicates that locus receptors variety important host defense.