The mast cell function-associated antigen, a new member of the ITIM family.
作者： R. Xu , I. Pecht
DOI: 10.1007/978-3-642-58537-1_14
关键词:
摘要: A decade has already passed since we discovered, essentially by serendipity, the membranal glycoprotein later named MAst cell Function-associated Antigen (MAFA). While trying to identify still elusive Ca2+ channel responding type 1 Fcɛ receptor (FcɛRI) stimulus, a series of monoclonal antibodies (mAb) were raised rat mucosal-type mast cells RBL-2H3 line. One these mAbs, G63, caused dose-dependent inhibition secretory response FcɛRI stimulus and was shown bind protein which proceeded isolate characterize (Ortega-Soto Pecht 1988).
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